AIM ImmunoTech Announces Late-Breaking Presentation at the International Conference on Antiviral Research Regarding Ampligen as a Potential Therapy Against Ebola Virus Disease

Growing body of data supports Ampligen’s potential as both a prophylactic and an early-onset therapy against human Ebola virus disease outbreaks

OCALA, Fla., March 16, 2023 (GLOBE NEWSWIRE) — AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM” or the “Company”), an immuno-pharma company focused on the research and development of therapeutics to treat multiple types of cancers, immune disorders, and viral diseases — including COVID-19, the disease caused by the SARS-CoV-2 virus — today announced a late-breaking presentation at the 36th International Conference on Antiviral Research (ICAR) detailing Ampligen’s mechanism of action in the treatment of Ebola virus disease (EVD).

The presentation was given by Angela Corona, PhD, Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy, and one of the published authors of a recent manuscript titled “Ebola virus disease: In vivo protection provided by the PAMP restricted TLR3 agonist rintatolimod and its mechanism of action.” Ebola virus (EBOV) is a highly infectious and lethal pathogen responsible for sporadic, self-limiting clusters of EVD in Central Africa capable of reaching epidemic status. Highlights of the recently published Ampligen data that was presented include:

  • As a TLR3 agonist, Ampligen induces and enhances innate immunological responses to EBOV infection.
  • Ampligen appears to inactivate the EBOV lethal factor (EBOV VP35), which is believed to be responsible, in part, for the high mortality rate observed in humans, by acting as a “competitive decoy.” VP35 is understood to sequester the dsRNA produced by EBOV during its replication, which inhibits the normal innate immune responses to viral infection.
  • Ampligen protected mice from a lethal challenge by mouse adapted EBOV-Zaire and its associated weight loss.
  • The 6 mg/kg doses, frequently used in AIM’s clinical trials, used in mouse model is easily achievable and well tolerated in humans.
  • Overall, the data suggest Ampligen’s potential as a viable candidate to protect against exposure to EBOV.

The corresponding slides from the presentation at ICAR are now available on the Company’s website ( on the “Events and Presentations” page.

AIM CEO Thomas K. Equels commented, “In vivo pre-clinical analysis shows that Ampligen has potential as both a prophylactic and an early-onset therapeutic in Ebola virus disease. Animal studies with Ampligen at the United States Army Medical Research Institute of Infectious Diseases Biosafety Level 4 laboratories demonstrated 100% protective survival, as compared to 100% mortality in Ebola virus disease. Those animal studies are indicative of the drug’s high potential for efficacy. The analysis presented at ICAR now provides a clear understanding of why Ampligen is achieving such a high level of efficacy in these animal models, signaling its potential as a human therapy.”

Ampligen has been granted Orphan Drug status for Ebola virus disease by the European Medicines Agency and the FDA. Ampligen is not currently approved for the prevention or treatment of EVD.

The Company intends to file Investigational New Drug applications to study the use of Ampligen (1) as an early onset therapy for the treatment of EBOV, and (2) for the prevention of Ebola virus reactivation. Ultimately, the Company’s goal is to seek a Tropical Disease Priority Review Voucher for new drug applications associated with these indications.

About the International Society for Antiviral Research (ISAR)

The International Society for Antiviral Research (ISAR) is an internationally recognized organization for scientists involved in basic, applied, and clinical aspects of antiviral research. The Society main event is the annual International Conference on Antiviral Research (ICAR), a truly interdisciplinary meeting which attracts the interest of chemists, biologists, and clinicians.

About Ampligen

Ampligen is AIM’s dsRNA product candidate being developed for globally important cancers, viral diseases and disorders of the immune system. Ampligen is currently being evaluated as a combinational therapy for the treatment of a variety of solid tumor types in multiple clinical trials – both underway and planned – at major cancer research centers around the country. Ampligen is being used to treat pancreatic cancer patients in an Early Access Program approved by the Inspectorate of Healthcare in the Netherlands at Erasmus Medical Center. Additionally, Ampligen is also approved in Argentina for the treatment of severe chronic fatigue syndrome and is currently being evaluated in SARS-CoV-2/COVID-19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Post COVID Conditions.

About AIM ImmunoTech Inc.

AIM ImmunoTech Inc. is an immuno-pharma company focused on the research and development of therapeutics to treat multiple types of cancers, immune disorders, and viral diseases, including COVID-19. The Company’s lead product, an investigational new drug called Ampligen® (rintatolimod) is an immuno-modulator with broad spectrum activity being investigated for globally important cancers, viral diseases and disorders of the immune system.

For more information, please visit and connect with the Company on Twitter, LinkedIn, and Facebook.

Cautionary Statement

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 (the “PSLRA”). Words such as “may,” “will,” “expect,” “plan,” “anticipate” and similar expressions (as well as other words or expressions referencing future events or circumstances) are intended to identify forward-looking statements. Many of these forward-looking statements involve a number of risks and uncertainties. The clinical study and other matters discussed above are subject to a number of unknowns including, but not limited to, that significant additional testing and trials will be required to determine whether Ampligen will be an effective treatment for Ebola virus, comments and additional testing requested by the FDA if and when the Company files the Investigational New Drug application and whether the Company will be able to obtain a Tropical Disease Priority Review Voucher for the new drug application. Among other things, for those statements, the Company claims the protection of safe harbor for forward-looking statements contained in the PSLRA. The Company does not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. Two of the authors of the manuscript are officers or directors of the Company. The information found on our website is not incorporated by reference into this press release and is included for reference purposes only.

Investor Relations Contact
Jenene Thomas

GlobeNewswire Distribution ID 8789385

Play Ball! Major League Baseball and Zoom Announce First-of-its-kind Partnership; Zoom Contact Center to Power ‘Zoom Replay Operations Center’

  • Zoom becomes Official Unified Communications Platform of MLB and Presenting Partner of MLB Replay Review
  • MLB to introduce league-first, broadcast look-ins from the Zoom Replay Operations Center
  • Zoom Contact Center, Zoom Events, and Zoom’s all-in-one collaboration platform will deliver unprecedented transparency to the fans and enhanced communications between front office staff, umpires, and league officials

SAN JOSE, Calif. and NEW YORK, March 16, 2023 (GLOBE NEWSWIRE) — Major League Baseball (MLB) and Zoom Video Communications, Inc. (NASDAQ: ZM) today announced a first-of-its-kind partnership for the league, aimed to enhance MLB games and the fan viewership experience. As the new Official Unified Communications Platform of MLB, Zoom Contact Center and the Zoom platform technology will power new elements of Major League games and broadcasts.

MLB Chief Operations & Strategy Officer Chris Marinak, said: “We are always looking for innovative ways to leverage best-in-class technology to advance the MLB experience and deliver more to our fans. Partnering with Zoom, a category leader that reinvented the way we connect, was a natural next step for us. We are excited to integrate Zoom Contact Center and other Zoom platform technology into our gameday operations and continue to modernize experiences in a secure, reliable, and innovative way.”

Zoom Chief Marketing Officer, Janine Pelosi said: “MLB brings together tens of millions of passionate fans every season. Zoom’s rapid pace of innovation and obsession with making human connection easier and better, is crucial to help MLB evolve its experience and deliver unprecedented transparency and access to its fans. With MLB leveraging Zoom Contact Center and Zoom’s all-in-one collaboration platform, we are able to truly show the world how a historical brand can continue to innovate and unlock new possibilities.”

Zoom platform integration drives MLB innovations:

  • Zoom Contact Center transforms replay review – In the 2022 MLB season, there were more than 1,400 replay reviews. Historically, the league’s replay review was reliant on disparate technology and audio-only communication with umpires on the field, resulting in fans being disconnected from the decision-making process.

    Beginning with the 2023 Season, the Crew Chief, the most senior member of the four-man umpire crew, will connect to the Zoom Replay Operations Center using Zoom’s Contact Center solution during any replay review. During national broadcasts on MLB Network and Apple TV+, fans will also see the Zoom Replay Operations Center in action live during replay reviews and hear from an expert rules analyst who will discuss replay reviews with the broadcast team. MLB’s goal with this new setup is to create a more transparent and engaging review process.

  • Zoom Platform helps streamline communication – Zoom will be used to securely deliver sensitive information in one of the most high-pressure and high-profile MLB Events, Day One of the 2023 MLB Draft.
  • Broader league-wide Zoom integrations advance collaboration – Zoom’s all-in-one collaboration platform is integrated across several MLB clubs, platforms, and broadcast outlets. In addition to Zoom Meetings, many MLB teams are using Zoom Phone to stay connected with colleagues and customers, as well as Zoom Contact Center to deliver prompt, accurate, and highly personalized customer experiences to their fans. MLB’s corporate offices use Zoom Meetings, Zoom Rooms, Zoom Phone, and Zoom Webinar to connect, collaborate, and communicate.

To learn more about the Zoom platform and the technology that will power several new elements in MLB starting in the 2023 season, read the blog here.

About MLB
Major League Baseball (MLB) is the most historic professional sports league in the United States and consists of 30 member clubs in the U.S. and Canada, representing the highest level of professional baseball. Led by Commissioner Robert D. Manfred, Jr., MLB remains committed to making an impact in the communities of the U.S., Canada and throughout the world, perpetuating the sport’s larger role in society and permeating every facet of baseball’s business, marketing, community relations and social responsibility endeavors. MLB currently features record levels of competitive balance, continues to expand its global reach through programming and content to fans all over the world, and registered records in games and minutes watched this season on MLB.TV. With the continued success of MLB Network and MLB digital platforms, MLB continues to find innovative ways for its fans to enjoy America’s National Pastime and a truly global game. For more information on Major League Baseball, visit

About Zoom
Zoom is an all-in-one intelligent collaboration platform that makes connecting easier, more immersive, and more dynamic for businesses and individuals. Zoom technology puts people at the center, enabling meaningful connections, facilitating modern collaboration, and driving human innovation through solutions like team chat, phone, meetings, omnichannel cloud contact center, smart recordings, whiteboard, and more, in one offering. Founded in 2011, Zoom is publicly traded (NASDAQ:ZM) and headquartered in San Jose, California. Get more info at

MLB Communications
David Hochman

Zoom Public Relations
Candace Dean

GlobeNewswire Distribution ID 8789553

Get the expert take on the African tax landscape at IBFD’s Masterclass

IBFD Masterclass: Tax Structuring in Africa – Selected Critical Issues

Masterclass returns to strengthen African taxation


IBFD will host the Masterclass: Tax Structuring in Africa – Selected Critical Issues, on 22-23 May 2023 in Arusha, Tanzania for African tax practitioners. This advanced-level training will provide participants with a platform to learn, share and debate the most pressing issues in international taxation.

African tax professionals such as tax managers and directors, in-house tax and accounting specialists in commerce and industry, practitioners in tax advisory firms, and government officials, will gain a deeper and practical understanding of the most important topics in international taxation, from a unique African perspective.

Which topics will the Masterclass programme cover?

  • Current Issues in International Taxation and Transfer Pricing from Around the Globe – Impact on African Inbound and Outbound Investments
  • Tax Treaty Policy in Africa: Impact of Treaty Anti-Avoidance Rules
  • Artificial Avoidance of Permanent Establishments: Experience from Around the Globe and Potential Lessons for Africa
  • Cross-Border Business Activities in Africa – Cross-Border Services and Withholding Tax Structuring

Find out more and benefit from the early-bird discount!
For more details on the programme objectives, course content, structure, trainers and to benefit from the 10% early-bird discount ending 20 March, visit

Contact information: Phil Windus, Senior Marketing Coordinator:

About IBFD
IBFD is a leading international provider of cross-border tax expertise, with a long-standing history of supporting and contributing to tax research and academic activities. As an independent foundation, IBFD utilizes its global network of tax experts and its Knowledge Centre to serve Fortune 500 companies, governments, international consultancy firms and tax advisers.

A photo accompanying this announcement is available at

GlobeNewswire Distribution ID 8789135

South Africa: Striking essential workers urged to return to work, failure subject to possible dismissal

South Africa’s Department of Health warned that any employee who fails to comply with the court order interdicting the current strike action will be committing an act of misconduct which is subject to disciplinary action, including possible dismissal.

This comes after the Labour Appeal Court issued a judgement that interdicts with immediate effect, strike action by the National Education, Health and Allied Workers’ Union (Nehawu) members and employees who are employed in essential services.

Nehawu has been on industrial action since March 6 due to the collapsed wage negotiations, with threats to intensify the strike action.

Workers are demanding a 10% salary increase, while government has offered 4.7%.

“Any person committing any criminal acts in pursuit of the strike action will be subjected to criminal proceedings by the law enforcement agencies. Over and above, what is stated [is that] all managers are obliged to apply the principle of ‘no work, no pay’, and this should be applied with immediate effect,” Minister Joe Phaahla said during a late-night briefing.

The court order, he said, “unequivocally” calls on Nehawu leadership to inform and call on all their essential services members to return to work with immediate effect.

“In consideration of practicality we have given the workers in the health sector until tomorrow [Tuesday] morning to report to work, failing which they will be in contempt of court and liable to face charges of misconduct. “

He said there is no doubt that the strike has disrupted the provision of essential healthcare services in the country, leading to untold suffering and frustration among the public who desperately needed healthcare and life-saving treatment and other interventions at public health facilities.

Last Thursday, Phaahla announced that four people had died “in a manner that could be directly attributed to the strike”.

The court judgement, he said, concurs with the view that has always been held by the ministry and the department that essential services workers are prohibited from engaging in disruptive industrial action, which is detrimental to healthcare services with a risk of loss of life, as provided by the Labour Relations Act.

“It is for this reason that Parliament enacted this Act in line with [the] Bill of Rights, whilst making provision of withdrawal of labour in general, however, it excluded essential services from this right.”

Meanwhile, he explained that to protect the rights of essential services workers, the law creates a mechanism for deadlock breaking through mediation, conciliation and arbitration.

“It is regrettable that this strike action has gone on causing untold hardship, pain, frustration and possible loss of life in its cause while it could have been avoided. It is inconceivable that the leadership of Nehawu were oblivious to the provisions of our law in this regard.”

The department reiterated the call as stipulated in both the court order and the Department of Public Service and Administration (DPSA) circular, which draws from the decision of the Labour Appeal Court, which restrains and prevents essential healthcare workers to participate in any such strike, picket or any other form of industrial action.

The Minister also took the time to apologise to all South Africans who have experienced pain, humiliation and suffering because of the strike.

On Monday morning, Phaahla told the media that 20 South African National Defence Force (SANDF) nurses were deployed due to shortages caused by the industrial action.

Source: Nam News Network (NNN)

Ministerial handbook guidelines are complied with, says Minister Ntshavheni

Minister in the Presidency, Khumbudzo Ntshavheni, has assured South Africans that Members of the Executive are compliant with the guidelines in the Ministerial handbook, which outline the benefits, tools of trade and allowances for Members of the Executive to perform their duties efficiently.

Addressing members of the media in Pretoria on Thursday, the Minister said Cabinet expressed concern over the continued misrepresentation of the Guide for Members of the Executive.

This follows complaints that have been reported in the media about the benefits received by Members of the Executive.

“The current configuration of the Executive responds to the service-delivery interventions outlined in both the State of the Nation Address and Budget Speech.

“In line with the guide, the State provides housing to members of the Executive and takes into account that Parliament is in Cape Town and the seat of the Executive is in Pretoria. The Groote Schuur Estate in Cape Town and the Bryntirion Estate in Pretoria, which were purchased prior to 1994, continue to be used to provide housing to Ministers and Deputy Ministers, only during their tenure,” Ntshavheni said.

She said the benefits Members of the National Executive receive are continually reviewed to advance good governance, particularly with regard to cost containment, cost effectiveness and efficiency.

“All Members of Parliament are entitled to support staff who assist them to account to their constituencies. Even so, in the area of support staff, the number of posts that could be created to support a Member of the Executive have been reduced. Support staff for Ministers were reduced from 13 to seven and for Members of the Executive Council (MEC) from 13 to five.

“Members of the Executive are often called to work outside of normal business hours and engage with stakeholders across the country. The package of benefits received is consistent with their skills, knowledge and experience to oversee their departments,” the Minister said.

She was addressing members of the media of the outcomes of Wednesday’s Cabinet meeting.

“The Ministerial benefits and those benefits extending to parliament across all provinces and including the parliament and members of the NCOP are a result of 1910, when they formed the Union of South Africa in our exclusion and decided on three capitals.

“It should be understood that since 1994, this government and this administration has never procured any new property so the adventurism that claims that Ministers live in mansions, those mansions are inherited and like any property the value accumulates if it is maintained.

“That is what has happened. The value has accumulated through the maintenance. Ministers pay rent for the second property that they utilize at a market related [rate]. We must understand that Ministers of this government do not come exclusively from Cape Town and Pretoria. They come from different parts of the country,” Ntshavheni said.

She noted the alternatives that are being proposed, which include utilising hotels.

“[They] are more expensive, in particular in Cape Town….that is why government uses the facilities of government that are in place to accommodate,” the Minister said.

She dismissed the notion that Ministerial houses are not loadshed.

“That is a fallacy. Ministerial houses are loadshed, they undergo loadshedding. The only exemption is the Bryntirion Estate because it sits in the National Key Point, which is the Union Buildings and Mahlamba Ndlopfu.

“We are not going to sacrifice the national security of this country because of political popularism that are attempted by all opposition parties towards elections,” Ntshavheni said.

She indicated that the National Treasury in consultation with the police approve vehicles according to safety standards.

“We cannot risk people’s lives because of political adventurism and claims for political popularity. The public must understand that Ministers are at the service of government and therefore they are entitled to be protected.

“In terms of the Ministerial handbook, we need to clarify the claim that some Ministers have more staff than other Ministers. That is not true. It is only a result of the time a particular Minister was appointed.

“The Ministerial handbook is a living document that is continuously revised. At some point, the support staff was at a higher number and at some point, the support staff was reduced. It depends on when a particular Minister was appointed,” Ntshavheni said.

The support staff is linked to the term of office of a Minister, unless a particular staff resigns during the term of office of that Minister, than that vacancy cannot be filled if that post has been destablished.

“If no member of staff resign, those support staff will remain as they are linked to the term of a particular Minister so there is no adventurism by some Ministers wanting more staff. We are all compliant to the Ministerial handbook,” she said.

The President has referred the Ministerial Handbook to the Commission of Independent Remuneration of Political Office Bearers who are already dealing with the salaries of Ministers, the President and members of parliament so that in totality they can look at support and benefits that they are entitled to and advise the President accordingly.

“We are waiting for their final report to be submitted,” the Minister said.

Source: South African Government News Agency

Government issues stern warning on attempts to cause disruption

Minister in the Presidency, Khumbudzo Ntshavheni, has warned that attempts to cause disruption and disturbances in the country will be met with the full might of the law.

This comes after the Economic Freedom Fighters (EFF) announced a national shutdown on Monday, 20 March, sparking concerns of disruptions.

Ntshavheni described the planned shutdown as irresponsible and reckless, saying the Justice, Crime Prevention and Security (JCPS) Cluster stands ready to deal with lawlessness.

The Minister was speaking during a post Cabinet media briefing on Thursday in Pretoria.

“The alleged demands about load shedding, the high cost of living and high unemployment rate were addressed by the President during the State of the Nation Address.

“Therefore, the only demand which is the basis for this protest action is the plan to remove President Ramaphosa from office through unconstitutional means. We want to inform all, that regime change through unconstitutional means will not be tolerated, and it will not happen in South Africa.

“Attempts to cause disruption and disturbances in the country will be met with the full might of the law,” the Minister said.

She urged those with ambitions to govern the country to wait for the 2024 General Elections.

“We must also clarify that no amount of political adventurism should stray South Africans. Cabinet has noted the hallucination of groupings claiming that they have given Cabinet seven days to shut down or close schools.

“The Government Gazette of March 2022 has already declared the 20th of March as a special school holiday for both public schools and private schools, so we should not claim easy victories. It won’t happen,” Ntshavheni said.

The Minister highlighted that schools will be closed and this is a trend like in any other country where a school holiday coincides with a normal holiday, and members of the public, who are in employment, and parents normally take long weekends.

“The majority of South Africans would have taken Monday the 20th as special leave or leave day so they can enjoy their long weekend.

“So people should not be fooled. If people are not at work, it is not because of the shutdown or calls for people not to go to work. If people are not at work, it is because people have long planned that they are going on holiday.

“There are not going to be easy victories that are claimed at the expense of this country,” Ntshavheni said.

Protection of property

Government has further assured all South Africans that Monday will be a normal business day and everyone and their property will be protected during the planned national shutdown.

The JCPS said this while briefing media on measures the cluster had put in place to minimise the impact of the national shutdown.

Police Minister Bheki Cele said government lauds residents and businesses who refuse to be intimidated or bullied by those planning the shutdown.

Cele said the JCPS has noted the planned protest action called by some groupings and the mobilisation undertaken on various communication platforms for members of the public to join the protest action.

“We want to assure everyone in the country that the 20th of March will be a normal business day. We want to reiterate to our international community that contrary to the pronouncements by those advocating for any disruption, all ports of entry – land, sea and air – will be operational.

“Measures have been put in place to ensure that everyone who wants to go to work, travel for leisure and conduct business on this day does so in a safe and secure environment,” Cele said.

He assured South Africans that law enforcement officers will be out in their numbers to protect them, whilst enforcing the law.

“Anyone who intimidates, stops anyone from going to work, barricades the roads and highways and uses any form of violence to try and stop our people from going on with their lives will face the full might of the law.”

The JCPS cluster also cautioned against the spreading of messages of fear, intimidation or inflammatory statements that could incite violence.

“This is a criminal offence. We are aware of many social media accounts claiming that hundreds and thousands of followers are being mobilised to support the protest.

“The majority of communities and various sectors of society including SANTACO [SA National Taxi Council], the National Taxi Association, the Road Freight Association and organised structures within communities, have rejected this call,” the Cluster said.

Cele said that they are aware that social media platforms are being used to give credence to the protest. He appealed to the public not to believe everything they read on social media.

“Government will be providing people with information through credible government channels,” the Minister said.

Cele said they will be closely monitoring the situation throughout the country, and will act swiftly and decisively against any threats or disruptions.

“There will be high police visibility. Our law enforcement agencies, through the NATJOINTS [National Joint Operational and Intelligence Structure], will ensure multidisciplinary deployments and the necessary contingency plans are already in place,” he said.

He said the NATJOINTS will be briefing the nation on its plans for the planned protest.

The cluster commended many associations in the sports, the transport sectors, the taxi industry, the trucking industry and others which have indicated they do not support any call for a shutdown for any protest action that will result in the disruption of their business on Monday.

The Minister of Defence and Military Veterans, Thandi Modise, assured that the South African National Defence Force is on standby.

Sporting events will continue as per their programmes by their different sports associations and all government services will be available, Cele said.

Heads of government departments and accounting officers in the public service will continue to ensure that citizens receive the services they expect from government.

Communities have been encouraged to report any form of criminality and intimidation to their nearest police station or call the Crime Stop number 08600 10111.

“We will ensure that businesses continue to operate on that day and roads are accessible.

“The Security Cluster is fully prepared and will deal with any disruption caused by this protest action. Those who will be participating in any form of protest action around the country must ensure that they do so in a peaceful manner. No form of violence and criminality will be tolerated,” Cele said. –

Source: South African Government News Agency